LSD1 （aa 400-450） Antibody （Lysine-specific histone demethylase 1A （BRAF35-HDAC complex protein BHC110） （Flavin-containing amine oxidase domain-containing protein 2））
供应商
Biovision
产品货号
6116-50
产品报价
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产品新闻
背景资料
LSD1 the first known lysine-specific histone demethylase， is an 866 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain， a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys4 of histone H3， a specific tag for epigenetic transcriptional activation. Reports suggest that that LSD1 plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide （might use alternative electron acceptors）. Along with nuclear FHL2， LSD1 serves as a novel biomarker predictive for prostate cancer.
应用类型
Western blot: 1-3 ug/ml. However， the optimal conditions should be determined individually.
免疫原
Synthetic peptide from a portion of human LSD1 amino acids 400-450
