GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene,called GHRd3,lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome,also known as the growth hormone insensitivity syndrome (GHIS),a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single,non-glycosylated,polypeptide chain containing 237 amino acids and having a molecular mass of 30.3 kDa.